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Anatomical Significance of the Connective Tissue Surrounding a Fascicle and Other Parts

The human anatomy is very complex and operates in ways that are mostly unrecognized by many people. Many people have vague knowledge on the different systems of the human body. The facts they know about the human anatomy are very basic, leading them to unknowingly abuse the parts of their body systems. They may know of certain things about major internal and external body parts but the more complicated and many oversee meticulous parts of the human body. For example, they may know that the nervous system is the system in which the brain is the major organ. It is the processor of everything the body does. However, it is possible that they do not recognize the miniscule parts that actually facilitate neural activities, resulting to bodily functions.

Every body system has larger organs that are fundamental parts: for the nervous system, the brain; for circulatory, the heart; for digestive, the stomach and the intestines; for genitourinary, the kidney and the genitals; and for musculoskeletal, the muscles and the bones. Nevertheless, these larger organs cannot standalone. They would not be able to perform their purposes without the tinier parts of the system. The processes of these smaller parts allow the systems to function as they are intended to, making them as major as the bigger parts. This means that every single part of the human body is essential.

The musculoskeletal system of the body is not an exception. Bones and muscles are the locomotive mechanism of the body. Without them, humans (and animals) would not be able to move about, and perform essential tasks such as eating, walking, and working. It consists of the skeleton, muscles, cartilages, tendons, joints, ligaments, and more connective tissues that attach organs and other tissues.

This system consists of two subsystems namely muscular and skeletal. Firstly, the muscular system is mostly muscles. There are three types of muscles. These are smooth, cardiac, and skeletal. Muscles that are classified as smooth are responsible for the flow control of certain substances. Heart muscles are called cardiac muscles because they are the ones that functions as blood circulator. These two types of muscles are involuntary, or muscles that are not consciously controlled.

The two types of muscles involved in musculoskeletal processes are skeletal and smooth. Conversely, only one type of muscle is employed during locomotive activities. The muscles responsible for movement are the skeletal muscles. Muscle fibers are collected in a bundle called fascicles. A connective tissue surrounding the fascicle (or the perimysium) keeps the bundle intact. This entire muscle bundle is enclosed in epimysium. Muscles fibers will not be able to move the skeleton if all of the muscles are one mass of muscles. They must be bundle for significant parts of the skeletal system. This allows the proper utilization of muscle fibers, and gives power to major parts of the skeleton. For example, muscle bundles can be found at the humerus for the arm to move.

Connective tissues are also the ones that join bones and muscles together.

Connective Tissues Vulnerability to Damage and Disease

Although connectives tissues are at the innermost parts of the human body, it can still be damaged and affected by diseases. The connective tissue surrounding a fascicle or any other connective tissue are at risk of procuring injury and illness. Damage may be obtained by overworking the musculoskeletal system of the body. Exerting too much effort all at once on the muscles and skeleton may also be a cause of damage.

Some studies show that genetics is the culprit for the increase of possibility of most documented connective tissue diseases. The environment, diet, and old age are also possible causes of connective tissues contraction of ailments. Symptoms of connective tissue damage and diseases are fevers and joint pains. A combination of stiff joints and weak muscles also indicates an unhealthy condition of connective tissues. This unfit state of the musculoskeletal element may be detected through physical examinations. However, if the doctor was not able to detect a corruption of connective tissues through physical inspections, but the symptom persists, he may conduct blood tests, x-ray examinations, and other tests that focus on the inner musculoskeletal structure. For more intensive analysis, and if necessary, a biopsy may be done. This can be done through obtaining a sample of the muscles that are suspected to have damages connective tissues. However, this is advised only to patients with very serious and fatal condition.

Genetically passed on connective tissue disorder includes Marfan Syndrome. It causes no irregular amounts fibrillin, which is a glycoprotein responsible for forming fibers that provide elasticity of connective tissues. Another connective tissue disease that can be inherited is the Ehlers-Danlos syndrome, which is the malfunction if the combination of collagens. It distresses body parts such as the heart, joints, and arteries.

One of the most common disease of the connective tissues is Rheumatoid arthritis. It is a sickness that causes the immune cells to attack the joint membranes, affecting that certain part, as well as the eyes, heart, and lungs.

Systemic lupus erythematosus or simply SLE is one of the most sever connective tissue disease. Inflammation of joints, internal organs, and joints occur causing hair loss, anemia, and kidney problems. Other symptoms include patients becoming sensitive to sunlight, ulcers at the mouth, rashes on cheeks and nose, heart fluid, and memory and concentration difficulty.

According to studies, the most dangerous disorder is the mixed connective tissue disease or MCTD. It is a combination of many diseases that occur in a connective tissue surrounding a fascicle or any other connective tissues. Considered an overlap syndrome, it causes the same effects as major diseases. Symptoms of this highly critical illness are malaise, inflammation of the muscles, thickening of skin around the fingertips, joint unease, and manifestations of many other syndromes.

Although one of the most hidden, the connective tissue surrounding a fascicle can also be affected. There is a condition called perimysial fragmentation, in which the perimysium is disintegrated into loculi. The cells on perimysium have larger nuclei, and projecting cytoplasm. The muscles that these connective tissues surround show signs of regeneration and necrosis. These connective tissues surrounding a fascicle can also be damaged.

Perimyositis is a chronic clinical condition in which there is muscle pain caused and made grave by activity and passive motion. Patients with perimyositis show normal levels of Serum CK, Eosinophilia, and EMG and NCV. In addition, an inflammation occurs on the muscles surrounded by the infected perimysium.

Perimysial widening occurs when a patient has focal myositis. It is a condition wherein the connective tissue surrounding a fascicle becomes infested by large cells that are surrounded by clear area. However, there is not necrosis and fragmentation of the perimysium occurs.

It is important to know not only the basics of human anatomy but also the most miniscule operations that happen in each anatomical system. It is wise to have a fair amount of knowledge on these things in order to take care of your body in the innermost way possible. As demonstrated above, large organs are not the only ones that have the possibility of procuring damages and diseases. Knowing how to take into consideration the littlest body part may help you prevent having fatal damages. It also helps you have a clue on mysterious symptoms that suddenly manifests themselves. You can tell your doctor if you suspect that you have obtained any of these connective tissue diseases, so as to avoid letting it develop into a much more complicated disorder.

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